The health care system is expected to become more complex and specialized. This calls for nurses with good skills in making judgments, taking action, and organizing patient care. At the Nursing school in Aarhus, Denmark, we meet these requirements by developing experimental teaching reflecting practice. Aim: To explore how the development of clinical imagination and relevance assessment can prepare nursing students for clinical studies and act as educated nurses. Methods: The study consists of qualitative interviews with students who have followed an experimental course and a regular course. Results: Clinical imagination and relevance assessment presented themselves in three themes: Experiencing context. Using imagination. Being part of a professional cooperation. Conclusion: Working with the entire range of nursing activities in a real-life department seems to contribute to the development of nursing students’ clinical imagination and ability to make relevance assessments, preparing them to act, organize, and cooperate in a complex, clinical practice.