Background and aim: 80-90% of all patients getting cancer treatment suffer from cancer-related fatigue (CRF) in their everyday life. However, this has not gained much attention in clinical practice. To improve our nursing practice this study focuses on how the patients experience and handle CRF in order to enhance the body of already known knowledge in a Danish context. Methods: Nine patients’ experiences were analysed and interpreted using a phenomenological hermeneutical approach. Data was collected through semi-structured interviews. Findings: When CRF set boundaries for the patients’ everyday life, they handle the CRF by; “Struggle to do what they use to do”, “Come to terms with CRT” and by “To surrender and to give in”. Conclusion: Patients experience CRF as tiredness, fatigue and exhaustion. To handle this they use their personal experience, which are not always adequate and consequently make the impact on their everyday life greater than necessary.