It is unclear how radiodermatitis affects patients receiving radiotherapy. The aim of this study is to investigate if radiodermatitis affects the patients’ quality of life. In this study, the Danish version of the Dermatology Life Quality Index was used, and the questionnaire was distributed to 90 women with breast cancer receiving radiotherapy. The results of the study show that radiodermatitis reduces patients’ quality of life. 85,6 % of patients reported that radiodermatitis affected their quality of life, and 53,4 % of patients answered that it had a substantial affect. Physical symptoms and clothing were reported to be the most problematic topics. Especially younger patients, patients with severe radio-dermatitis, and patients receiving additional boost or chemotherapy experienced a major reduction in their quality of life. The results may lead to an adjustment of patient information and argue for the continued conduction of skincare to patients receiving radiotherapy.