Different understandings of the phenomena health and disease may have consequences for the clinical nurse. Evidence-based medicine (EBM) has a strong foothold in nursing. Practical knowledge, proficiency, and judgment acquired by the individual clinicians through clinical experience are no longer reliable sources of knowledge. There is an element of risk attached to not following the best available, external clinical evidence from systematic research. Also, there may be some risk involved if the clinical judgment does not see risk as an opportunity to interact. David Sackett, one of the pioneers of evidence-based medicine (EBM), reminds clinicians of the importance of integrating individual expertise and best external evidence. If clinical practice is guided by research activity alone, and if practical intuition and clinical judgment are ignored, the practice will become too generalized, and not enough attention will be paid to what is unique for each individual case.