Health politics, healthcare professionals, and a growing number of patients request greater patient participation in the interaction between patients and healthcare professionals. A review based on literature has been carried out on the basis of a literature search in the databases: Cinahl, PubMed and Swemed+. The aim was to investigate the present literature about nurse-patient interaction. It turned out that no unequivocal and clear definition exists; it is complex with several interpretations. Common for all interpretations is the emphasis on forming a relation with the patient and on decision-making processes, relating to their health and wellbeing. This article contributes to making research-based knowledge more accessible to clinical nurses and to further investigation.